Metabolic Research Peptide

Tirzepatide

Tirzepatide is a synthetic peptide agonist of the GIP and GLP-1 receptors, studied across a large phase 3 clinical-trial programme. Atlas RND supplies it as a lyophilized research peptide for laboratory research use only.

Read the 14 published studies

Last updated

For laboratory research use only. The literature below is provided for educational reference by qualified researchers. It is not medical advice, and nothing on this page is a claim about Tirzepatide. Not for human or veterinary use.

Published research · 14 studies

Published research on Tirzepatide

Peer-reviewed studies grouped by what they investigated, with human clinical trials first, then reviews, then laboratory work. Each links to the original paper.

Obesity clinical trials 5 studies

Human clinical trial The New England Journal of Medicine · 2022

Study title: Tirzepatide Once Weekly for the Treatment of Obesity.

DOI 10.1056/NEJMoa2206038 · PMID 35658024
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2025

Study title: Tirzepatide for Obesity Treatment and Diabetes Prevention.

DOI 10.1056/NEJMoa2410819 · PMID 39536238
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2025

Study title: Tirzepatide as Compared with Semaglutide for the Treatment of Obesity.

DOI 10.1056/NEJMoa2416394 · PMID 40353578
Read the study ↗
Human clinical trial The Lancet · 2023

Study title: Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

DOI 10.1016/S0140-6736(23)01200-X · PMID 37385275
Read the study ↗
Human clinical trial The Lancet · 2026

Study title: Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.

DOI 10.1016/S0140-6736(26)00656-2 · PMID 42119587
Read the study ↗

Type 2 diabetes clinical trials 5 studies

Human clinical trial The Lancet · 2021

Study title: Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial.

DOI 10.1016/S0140-6736(21)01324-6 · PMID 34186022
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2021

Study title: Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.

DOI 10.1056/NEJMoa2107519 · PMID 34170647
Read the study ↗
Human clinical trial The Lancet · 2021

Study title: Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial.

DOI 10.1016/S0140-6736(21)01443-4 · PMID 34370970
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2025

Study title: Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes.

DOI 10.1056/NEJMoa2505928 · PMID 41406444
Read the study ↗
Human clinical trial The Lancet · 2018

Study title: Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial.

DOI 10.1016/S0140-6736(18)32260-8 · PMID 30293770
Read the study ↗

Heart, liver and sleep apnea trials 3 studies

Human clinical trial The New England Journal of Medicine · 2025

Study title: Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.

DOI 10.1056/NEJMoa2410027 · PMID 39555826
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2024

Study title: Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.

DOI 10.1056/NEJMoa2404881 · PMID 38912654
Read the study ↗
Human clinical trial The New England Journal of Medicine · 2024

Study title: Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis.

DOI 10.1056/NEJMoa2401943 · PMID 38856224
Read the study ↗

Discovery and pharmacology 1 study

Discovery and phase 1 study Molecular Metabolism · 2018

Study title: LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.

DOI 10.1016/j.molmet.2018.09.009 · PMID 30473097
Read the study ↗

Important research notice. These studies are posted for research reference only. Titles are reproduced exactly as their authors published them and describe what those researchers investigated; they are not claims by Atlas RND about any product. Not for human consumption. All literature is provided for educational reference only and must not be interpreted as medical advice or product claims. Studies of a compound by other groups are not studies of Atlas RND material. By purchasing from Atlas RND you confirm you are a qualified researcher and will use products in accordance with all applicable laws and regulations. Back to the research library →

Molecular profile

TypeSynthetic 39-residue lipopeptide
CAS number2023788-19-2
Molecular weight4813.5 g/mol
Amino acids39
SynonymLY3298176
FormulaC225H348N48O68
↗ PubChem database

Quality and lot testing

Current lotDBR-60-257-26
Purity (current lot)99.84%
LaboratoryFreedom Diagnostics Testing
ReportedOct 1, 2026
Certificate of Analysis for lot DBR-60-257-26 →

Related compounds

Retatrutide · NAD+ · Wolverine Stack · Glow · BPC-157 · TB-500 · GHK-Cu · DSIP · MOTS-C · Tirzepatide product page