Metabolic Research Peptide

Retatrutide

Retatrutide is a synthetic investigational peptide that acts at three receptors (GIP, GLP-1 and glucagon), studied in phase 2 and phase 3 clinical trials. Atlas RND supplies it as a lyophilized research peptide for laboratory research use only.

Read the 9 published studies

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For laboratory research use only. The literature below is provided for educational reference by qualified researchers. It is not medical advice, and nothing on this page is a claim about Retatrutide. Not for human or veterinary use.

Published research · 9 studies

Published research on Retatrutide

Peer-reviewed studies grouped by what they investigated, with human clinical trials first, then reviews, then laboratory work. Each links to the original paper.

Obesity clinical trials 3 studies

Human clinical trial The New England Journal of Medicine · 2026

Study title: Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.

DOI 10.1056/NEJMoa2604169 · PMID 42814954
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Human clinical trial The New England Journal of Medicine · 2023

Study title: Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.

DOI 10.1056/NEJMoa2301972 · PMID 37366315
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Human clinical trial The Lancet · 2026

Study title: Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.

DOI 10.1016/S0140-6736(26)01861-1 · PMID 42810372
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Type 2 diabetes clinical trials 3 studies

Human clinical trial The Lancet · 2026

Study title: Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial.

DOI 10.1016/S0140-6736(26)00967-0 · PMID 42250575
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Human clinical trial The Lancet · 2023

Study title: Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.

DOI 10.1016/S0140-6736(23)01053-X · PMID 37385280
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Human clinical trial The Lancet Diabetes & Endocrinology · 2025

Study title: Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.

DOI 10.1016/S2213-8587(25)00092-0 · PMID 40609566
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Liver research 1 study

Human clinical trial Nature Medicine · 2024

Study title: Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.

DOI 10.1038/s41591-024-03018-2 · PMID 38858523
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Knee osteoarthritis and sleep apnea trials (design) 1 study

Trial design Diabetes, Obesity and Metabolism · 2026

Study title: Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials.

DOI 10.1111/dom.70209 · PMID 41090431
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Discovery and pharmacology 1 study

Discovery and phase 1 study Cell Metabolism · 2022

Study title: LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.

DOI 10.1016/j.cmet.2022.07.013 · PMID 35985340
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Important research notice. These studies are posted for research reference only. Titles are reproduced exactly as their authors published them and describe what those researchers investigated; they are not claims by Atlas RND about any product. Not for human consumption. All literature is provided for educational reference only and must not be interpreted as medical advice or product claims. Studies of a compound by other groups are not studies of Atlas RND material. By purchasing from Atlas RND you confirm you are a qualified researcher and will use products in accordance with all applicable laws and regulations. Back to the research library →

Molecular profile

TypeSynthetic 39-residue peptide
CAS number2381089-83-2
Molecular weight4731.3 g/mol
Amino acids39
SynonymLY3437943
FormulaC221H342N46O68
↗ PubChem database

Quality and lot testing

Current lotTBR-10-285-26
Purity (current lot)99.95%
LaboratoryFreedom Diagnostics Testing
ReportedOct 24, 2026
Certificate of Analysis for lot TBR-10-285-26 →

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